Cancer-terminal tycoon Peter Murdoch's secret Wexel Hall Pharmaceuticals lab has developed a blood orchid extract cure. To examine why it works optimally in snakes, they also bread a super-anaconda strain. But the original pair escapes, leaving a bloody trail of human corpses. Murdoch runs, instructing his staff to clean up. They keep failing and being eaten like unsuspecting locals, some alive, even after enlisting ruthless big game hunter Hammett. The fast-growing pregnant monster sheds its skin, thus disabling the only tracking device they have.
Unfortunately the movie Anaconda 3: Offspring is not yet available on Disney Plus.
| Writing | Nicholas Davidoff | Writer |
| Directing | Don E. FauntLeRoy | Director |
| Writing | David C. Olson | Writer |
| Sound | Peter Meisner | Original Music Composer |
| Art | Vlad Roseanu | Art Direction |
| Camera | Don E. FauntLeRoy | Director of Photography |
| Art | Șerban Porupcă | Production Design |
| Costume & Make-Up | Ana Maria Cucu | Costume Design |
| Production | Alison Semenza | Producer |
| Editing | Scott Conrad | Editor |
| Production | Bryan S. Sexton | Co-Producer |
| Production | Vlad Păunescu | Co-Producer |
| Production | Benjamin Sacks | Line Producer |
| Art | Gina Calin | Set Decoration |
| Production | Jeff Gerrard | Casting |
| Costume & Make-Up | Letitia Ghenea | Key Hair Stylist |
| Costume & Make-Up | Daniela Bușoiu | Key Makeup Artist |
| Costume & Make-Up | Ionel Popa | Makeup Designer |
| Costume & Make-Up | Adelina Handuri | Hairstylist |
| Production | Cristian Bostanescu | Executive In Charge Of Production |
| Crew | Ionel Popa | Special Effects |
| Crew | Vasile Albineț | Stunt Coordinator |
| Crew | G. Peter King | Stunt Coordinator |
| Crew | Gabi Burlacu | Stunts |
| Crew | Vlad Iacob | Stunts |
| Crew | Razvan Gheorghiu | Stunts |
| Crew | Valeriu Tomescu | Stunt Double |
| Crew | Mihai Iliescu | Stunts |
| Lighting | Calin Catalin | Gaffer |
| Production | Floriela Grapini | Casting |
| Directing | G. Peter King | Second Unit Director |
| Directing | Maria Nita | Second Assistant Director |
| Sound | Trip Brock | Supervising Sound Editor |
| Sound | Kyle Tilbury | Sound Re-Recording Mixer |
| Sound | Mark Hensley | Sound Re-Recording Mixer |
| Crew | Lucian Iordache | Special Effects |
| Visual Effects | James Allan May | VFX Artist |
| Visual Effects | Adam Clark | Visual Effects |
| Visual Effects | Gretchen McNelis | Visual Effects |
| Visual Effects | P.J. Foley | Visual Effects Producer |
| Visual Effects | David Van Woert | Visual Effects Producer |
| Camera | Gabriel Kosuth | "A" Camera Operator |
| Camera | Toni Cartu | Camera Operator |
| Camera | Merav Maroody | Still Photographer |
| Camera | Pãtru Pãunescu | Camera Operator |
| Directing | Cornelia Stefan | Script Supervisor |
| Production | Adrian Conerth | Unit Production Manager |
| Costume & Make-Up | Allen Payne | Hairstylist |
| Costume & Make-Up | Allen Payne | Makeup Artist |
| Costume & Make-Up | Mihaela David | Costume Supervisor |
| Art | Viorel Ghenea | Property Master |
| Sound | Nicolae Radu | Sound Mixer |
| Crew | Mircea Frenkel | Special Effects Technician |
| Production | Adrian Conerth | Production Manager |
| Production | Oana Topliceanu | Production Coordinator |
| Visual Effects | Adam Clark | Visual Effects Supervisor |
| Sound | Steven Avila | Sound Designer |
