Set 15 years after "Twentieth Century Boys," Kanna (Airi Taira) reunites with several main characters from the first film in an attempt to stop Friend's increasing influence over the world and continued plans to eliminate humanity, as detailed in the New Book of Prophecy.
Unfortunately the movie 20th Century Boys 2: The Last Hope is not yet available on Disney Plus.
| Writing | Yashushi Fukuda | Writer |
| Production | Nobuyuki Iinuma | Producer |
| Production | Ryûji Ichiyama | Producer |
| Production | Morio Amagi | Producer |
| Production | Futoshi Ohira | Producer |
| Editing | Nobuyuki Ito | Editor |
| Camera | Satoru Karasawa | Director of Photography |
| Production | Seiji Okuda | Executive Producer |
| Directing | Yukihiko Tsutsumi | Director |
| Writing | Naoki Urasawa | Comic Book |
| Visual Effects | Kôji Nozaki | VFX Supervisor |
| Sound | Audio Highs | Music |
| Directing | Tatsuya Shirashi | Assistant Director |
| Lighting | Akio Kimura | Gaffer |
| Production | 吉崎秀一 | Production Manager |
| Art | Naoki Soma | Production Design |
| Sound | Mitsuo Tokita | Sound Recordist |
| Production | Shinji Saito | Casting |
| Production | Kiyoshi Inoue | Line Producer |
| Crew | Yuta Morokaji | Stunt Coordinator |
| Sound | Ryomei Shirai | Original Music Composer |
| Sound | Toru Hasebe | Original Music Composer |
| Sound | Ryomei Shirai | Music Producer |
