Khaila Richards, a crack-addicted single mother, accidentally leaves her baby in a dumpster while high and returns the next day in a panic to find he is missing. In reality, the baby has been adopted by a warm-hearted social worker, Margaret Lewin, and her husband, Charles. Years later, Khaila has gone through rehab and holds a steady job. After learning that her child is still alive, she challenges Margaret for the custody.
Unfortunately the movie Losing Isaiah is not yet available on Disney Plus.
| Production | Hawk Koch | Producer |
| Production | Naomi Foner | Producer |
| Directing | Stephen Gyllenhaal | Director |
| Writing | Seth Margolis | Novel |
| Writing | Naomi Foner | Screenplay |
| Costume & Make-Up | Mary Malin | Costume Design |
| Art | William Arnold | Art Direction |
| Sound | Mark Isham | Original Music Composer |
| Production | Sharon Owyang | Associate Producer |
| Art | Jeannine Oppewall | Production Design |
| Editing | Harvey Rosenstock | Editor |
| Production | Aleta Chappelle | Casting |
| Art | Jay Hart | Set Decoration |
| Camera | Andrzej Bartkowiak | Director of Photography |
| Production | Kimberly Brent | Associate Producer |