Professor Charles Xavier and his team of genetically gifted superheroes face a rising tide of anti-mutant sentiment led by Col. William Stryker. Storm, Wolverine and Jean Grey must join their usual nemeses—Magneto and Mystique—to unhinge Stryker's scheme to exterminate all mutants.
| Writing | Zak Penn | Story |
| Writing | David Hayter | Story |
| Writing | Bryan Singer | Story |
| Writing | Michael Dougherty | Screenplay |
| Writing | Dan Harris | Screenplay |
| Writing | David Hayter | Screenplay |
| Directing | Bryan Singer | Director |
| Crew | Terry Notary | Choreographer |
| Editing | Elliot Graham | Co-Editor |
| Visual Effects | Michael L. Fink | Visual Effects Supervisor |
| Costume & Make-Up | Gordon J. Smith | Special Effects Makeup Artist |
| Production | Ross T. Fanger | Unit Production Manager |
| Production | Stewart Bethune | Unit Production Manager |
| Directing | Lee Cleary | First Assistant Director |
| Directing | David Arnold | Second Assistant Director |
| Production | Jason McGatlin | Production Supervisor |
| Art | Barbara Wilson | Assistant Art Director |
| Art | Brentan Harron | Assistant Art Director |
| Art | Ignacio McBurney | Assistant Set Decoration |
| Art | Ron Sowden | Assistant Set Decoration |
| Art | Franziska Keller | Art Department Coordinator |
| Art | Aimee Rousey | Art Department Coordinator |
| Directing | Gerrod Shully | Second Second Assistant Director |
| Directing | Silver Butler | Third Assistant Director |
| Camera | Tim Merkel | Steadicam Operator |
| Camera | Tim Merkel | "B" Camera Operator |
| Camera | Jimmy E. Jensen | First Assistant "A" Camera |
| Camera | Sean M. Harding | First Assistant "B" Camera |
| Camera | Kerry Hayes | Still Photographer |
| Camera | Doane Gregory | Still Photographer |
| Sound | Rob Young | Sound Mixer |
| Sound | Jon Lavender | Boom Operator |
| Crew | Andy Bishop | Cableman |
| Art | Jimmy Chow | Property Master |
| Art | Catherine Leighton | Assistant Property Master |
| Art | Jason B. Landels | Assistant Property Master |
| Crew | Rob Fournier | Armorer |
| Camera | Steve Smith | Key Grip |
| Costume & Make-Up | Cathy Crandall | Assistant Costume Designer |
| Costume & Make-Up | Janice Swayze | Costume Coordinator |
| Editing | Dov Samuel | First Assistant Editor |
| Sound | John A. Larsen | Supervising Sound Editor |
| Sound | Paul Massey | Sound Re-Recording Mixer |
| Sound | Doug Hemphill | Sound Re-Recording Mixer |
| Sound | Michael Herbick | Sound Re-Recording Mixer |
| Sound | Susan Dawes | Dialogue Editor |
| Sound | Jim Brookshire | Dialogue Editor |
| Sound | Donald Sylvester | ADR Supervisor |
| Sound | Laura Graham | ADR Editor |
| Sound | John Morris | Foley Supervisor |
| Sound | Amanda Goodpaster | Music Editor |
| Editing | Gary Burritt | Negative Cutter |
| Editing | Jim Passon | Color Timer |
| Editing | Chris Regan | Color Timer |
| Editing | Elliot Graham | Editor |
| Production | Lauren Shuler Donner | Producer |
| Production | Ralph Winter | Producer |
| Camera | Newton Thomas Sigel | Director of Photography |
| Editing | John Ottman | Editor |
| Art | Guy Hendrix Dyas | Production Design |
| Art | Helen Jarvis | Art Direction |
| Art | Elizabeth Wilcox | Set Decoration |
| Costume & Make-Up | Louise Mingenbach | Costume Design |
| Crew | Dane Farwell | Stunts |
| Production | Roger Mussenden | Casting |
| Visual Effects | Angie Jones | Animation |
| Visual Effects | Andy Asperin | Animation |
| Crew | Lauro David Chartrand-DelValle | Stunts |
| Crew | James Bamford | Stunts |
| Crew | J.J. Makaro | Stunts |
| Crew | Doug Chapman | Stunts |
| Sound | Michael Herbick | Sound Mixer |
| Art | Geoff Hubbard | Supervising Art Director |
| Crew | Jeffrey Cassidy | Video Assist Operator |
| Production | Kevin Feige | Co-Producer |
| Directing | Christine Wilson | Script Supervisor |
| Visual Effects | Andrew Tamandl | VFX Artist |
| Sound | John Ottman | Original Music Composer |
| Art | Rick Newsome | Storyboard Designer |
| Crew | Melissa R. Stubbs | Stunt Coordinator |
| Crew | Rick Pearce | Stunts |
| Crew | Marny Eng | Stunt Double |
| Production | Avi Arad | Executive Producer |
| Production | Tom DeSanto | Executive Producer |
| Production | Ross T. Fanger | Co-Producer |
| Production | David Gorder | Associate Producer |
| Production | Stan Lee | Executive Producer |
| Production | John H. Radulovic | Line Producer |
| Production | Selwyn Roberts | Line Producer |
| Production | Bryan Singer | Executive Producer |
| Directing | Brian Smrz | Second Unit Director |
| Visual Effects | Ray McIntyre Jr. | Visual Effects Supervisor |
| Art | Melanie Cassidy | Art Department Assistant |
| Visual Effects | Stephen Rosenbaum | Visual Effects Supervisor |
| Sound | Natalie Leggett | Musician |
| Crew | Angela Uyeda | Stunts |
| Art | Angelina Padron | Art Department Coordinator |
| Visual Effects | Gregory Galliani | Visual Effects Supervisor |
| Visual Effects | Paul Taglianetti | Visual Effects Supervisor |
| Costume & Make-Up | Cathy Darby | Costumer |
| Visual Effects | Scott Dougherty | Visual Effects Supervisor |
| Sound | William Stein | Recording Supervision |
| Crew | Gillian Richards | Scenic Artist |
| Camera | Charles Crivier | Dolly Grip |
