Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.
Unfortunately the movie The Opposite Sex is not yet available on Disney Plus.
| Writing | Fay Kanin | Screenplay |
| Directing | David Miller | Director |
| Costume & Make-Up | Helen Rose | Costume Design |
| Writing | Michael Kanin | Screenplay |
| Costume & Make-Up | William Tuttle | Makeup Artist |
| Production | Joe Pasternak | Producer |
| Art | Cedric Gibbons | Art Direction |
| Costume & Make-Up | Sydney Guilaroff | Hairstylist |
| Sound | Nicholas Brodszky | Songs |
| Sound | George Stoll | Songs |
| Writing | Ralph Freed | Lyricist |
| Directing | George Rhein | Assistant Director |
| Camera | Robert J. Bronner | Director of Photography |
| Sound | Irving Aaronson | Music Coordinator |
| Sound | Albert Sendrey | Orchestrator |
| Sound | George Stoll | Music Supervisor |
| Sound | Robert Van Eps | Original Music Composer |
| Editing | John McSweeney Jr. | Editor |
| Art | Henry Grace | Set Decoration |
| Crew | Warren Newcombe | Special Effects |
| Art | Daniel B. Cathcart | Art Direction |
| Writing | Sammy Cahn | Lyricist |
| Directing | Robert Sidney | Stage Director |
| Writing | Clare Boothe Luce | Theatre Play |
| Art | Edwin B. Willis | Set Decoration |
| Editing | Charles K. Hagedon | Editorial Consultant |
| Sound | Wesley C. Miller | Recording Supervision |
| Sound | Kendrick Kinney | Sound Editor |
| Crew | A. Arnold Gillespie | Special Effects |
| Sound | John Lipow | Sound Editor |
| Sound | Robert Van Eps | Orchestrator |
| Sound | George Stoll | Original Music Composer |