When a massive, unmanned locomotive roars out of control, the threat is more ominous than just a derailment. The train is laden with toxic chemicals, and an accident would decimate human life and cause an environmental disaster. The only hope of bringing the train to a safe stop is in the hands of veteran engineer Frank Barnes, and young conductor Will Colson, who must risk their lives to save those in the runaway's path. Inspired by true events.
| Writing | Mark Bomback | Writer |
| Production | Julie Yorn | Producer |
| Production | Mimi Rogers | Producer |
| Directing | Tony Scott | Director |
| Production | Eric McLeod | Producer |
| Production | Tony Scott | Producer |
| Production | Jeff Kwatinetz | Executive Producer |
| Camera | Ben Seresin | Director of Photography |
| Production | Chris Ciaffa | Executive Producer |
| Production | Alex Young | Producer |
| Production | Rick Yorn | Executive Producer |
| Art | Dawn Swiderski | Art Direction |
| Editing | Robert Duffy | Editor |
| Costume & Make-Up | Edouard F. Henriques III | Makeup Department Head |
| Editing | Chris Lebenzon | Editor |
| Art | Rosemary Brandenburg | Set Decoration |
| Art | Julian Ashby | Art Direction |
| Production | Denise Chamian | Casting |
| Costume & Make-Up | Stacy Horn | Costume Supervisor |
| Art | Denise Hudson | Art Direction |
| Art | Chris Seagers | Production Design |
| Art | Drew Boughton | Art Direction |
| Crew | Clay Cullen | Stunts |
| Crew | Michael Runyard | Stunt Driver |
| Crew | Keith Campbell | Stunt Driver |
| Crew | Jeremy Fry | Stunt Double |
| Sound | Harry Gregson-Williams | Original Music Composer |
| Sound | Nerses Gezalyan | Sound Mixer |
| Sound | William B. Kaplan | Production Sound Mixer |
| Camera | Robert Zuckerman | Still Photographer |
| Crew | Chuck Picerni Jr. | Stunt Coordinator |
| Art | Eugene McCarthy | Property Master |
| Camera | Mark Meyers | Steadicam Operator |
| Costume & Make-Up | Danny Moumdjian | Hair Designer |
| Costume & Make-Up | Yolanda Toussieng | Hair Department Head |
| Camera | John T. Connor | Camera Operator |
| Camera | Darin Moran | Camera Operator |
| Lighting | Scott Sprague | Lighting Technician |
| Costume & Make-Up | Wyatt Belton | Key Hair Stylist |
| Costume & Make-Up | Carl Fullerton | Makeup Artist |
| Camera | Martin Schaer | Camera Operator |
| Crew | Bruno Van Zeebroeck | Special Effects Coordinator |
| Costume & Make-Up | Diane Dixon | Hairstylist |
| Art | Carla S. Nemec | Art Department Coordinator |
| Art | Christina Romney-Glotzer | Art Department Coordinator |
| Visual Effects | Michael Shelton | Lead Animator |
| Costume & Make-Up | Larry M. Cherry | Hairstylist |
| Visual Effects | Duane Floch | Pre-Visualization Supervisor |
| Camera | Michael Wahl | Dolly Grip |
| Camera | Ralph Del Castillo | Dolly Grip |
| Lighting | Simone Perusse | Lighting Technician |
| Costume & Make-Up | Sandra Linn Koepper | Makeup Artist |
| Art | Mike Villarino | Construction Coordinator |
| Crew | Jason Schugardt | CG Supervisor |
| Crew | Bret St. Clair | CG Supervisor |
| Camera | John Skotchdopole | Camera Operator |
| Visual Effects | Diana Cheng | Visual Effects Coordinator |
| Visual Effects | Kimberly Covate | Visual Effects Producer |
| Visual Effects | Paul O'Shea | Visual Effects Supervisor |
| Costume & Make-Up | Rachel Kick | Makeup Artist |
| Lighting | Joshua Stern | Rigging Gaffer |
| Lighting | Dan Jarrell | Rigging Grip |
| Costume & Make-Up | Debi Young | Makeup Artist |
| Lighting | Pat Dames | Rigging Grip |
| Crew | Kosta Saric | Visual Effects Editor |
| Visual Effects | Elayaraja | Visual Effects Coordinator |
| Crew | Jose Marra | Visual Effects Editor |
| Art | Dale DeStefani | Construction Coordinator |
| Lighting | Skip Haswell | Rigging Grip |
| Costume & Make-Up | Diane Heller | Key Makeup Artist |
| Crew | Mark Mahoney | Tattooist |
| Costume & Make-Up | Natasha Ladek | Wigmaker |
| Visual Effects | John Frazier | Special Effects Supervisor |
| Crew | Joe Pancake | Special Effects Coordinator |
| Sound | Mark P. Stoeckinger | Supervising Sound Editor |
| Crew | Gary Powell | Stunt Coordinator |
| Lighting | Jack English | Gaffer |
| Directing | Adam Somner | First Assistant Director |
| Production | Adam Somner | Co-Producer |
| Art | Glenn Hoofman | Art Department Coordinator |
| Art | Glenn Hoofman | Art Department Coordinator |
| Art | Glenn Hoofman | Art Department Coordinator |
| Production | Yvette Gonzalez | Post Production Coordinator |
| Production | Skip Chaisson | Co-Producer |
| Production | Lee Trink | Co-Producer |
| Production | Diane L. Sabatini | Co-Producer |
| Costume & Make-Up | Penny Rose | Costume Designer |