Eccentric consulting detective Sherlock Holmes and Doctor John Watson battle to bring down a new nemesis and unravel a deadly plot that could destroy England.
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| Sound | Hans Zimmer | Music |
| Directing | Guy Ritchie | Director |
| Production | Joel Silver | Producer |
| Production | Bruce Berman | Executive Producer |
| Camera | Philippe Rousselot | Director of Photography |
| Sound | James Mather | Supervising Sound Editor |
| Production | Lionel Wigram | Producer |
| Writing | Lionel Wigram | Screenstory |
| Writing | Simon Kinberg | Screenplay |
| Sound | Ron Bartlett | Sound Re-Recording Mixer |
| Costume & Make-Up | Jenny Beavan | Costume Design |
| Production | Michael Tadross | Executive Producer |
| Writing | Arthur Conan Doyle | Characters |
| Production | Dana Goldberg | Executive Producer |
| Art | Sarah Greenwood | Production Design |
| Art | Nick Gottschalk | Art Direction |
| Art | Katie Spencer | Set Decoration |
| Production | Susan Downey | Producer |
| Sound | Derek Trigg | Foley Editor |
| Editing | James Herbert | Editor |
| Camera | Julian Bucknall | First Assistant Camera |
| Editing | Philip Hedgecock | First Assistant Editor |
| Production | Steve Clark-Hall | Producer |
| Writing | Anthony Peckham | Screenplay |
| Writing | Michael Robert Johnson | Screenplay |
| Writing | Michael Robert Johnson | Screenstory |
| Production | Dan Lin | Producer |
| Production | Peter Eskelsen | Producer |
| Sound | Kevin Kaska | Orchestrator |
| Art | Matthew Gray | Art Direction |
| Sound | Andrew Schmetterling | Boom Operator |
| Crew | Michael Bloomberg | Thanks |
| Art | Bradley Schmidt | Assistant Art Director |
| Crew | Richard Ryan | Stunts |
| Directing | Elizabeth West | Script Supervisor |
| Art | James Foster | Art Direction |
| Crew | Heather Phillips | Stunts |
| Sound | Andy Kennedy | Sound Effects Editor |
| Production | Reg Poerscout-Edgerton | Casting |
| Art | Niall Moroney | Supervising Art Director |
| Visual Effects | Mark Holt | Special Effects Supervisor |
| Crew | Nina Armstrong | Stunts |
| Visual Effects | Chas Jarrett | Visual Effects Supervisor |
| Camera | Alex Bailey | Still Photographer |
| Lighting | Jack English | Chief Lighting Technician |
| Costume & Make-Up | Clare Spragge | Costume Supervisor |
| Visual Effects | Jonathan Fawkner | Visual Effects Supervisor |
| Art | Dennis Wiseman | Property Master |
| Sound | Michael Fentum | Sound Designer |
| Sound | Dominic Gibbs | Sound Effects Editor |
| Visual Effects | Dadi Einarsson | Animation Supervisor |
| Sound | Peter Oso Snell | Music Editor |
| Costume & Make-Up | Patricia Regan | Makeup Artist |
| Lighting | Chuck Finch | Gaffer |
| Sound | Doug Hemphill | Sound Re-Recording Mixer |
| Art | Elliot Scott | Runner Art Department |
| Sound | Becki Ponting | Dialogue Editor |
| Art | Matthew Robinson | Assistant Art Director |
| Art | Helen Xenopoulos | Assistant Art Director |
| Costume & Make-Up | Arlynn Abseck | Wardrobe Supervisor |
| Crew | Jeff Brink | Special Effects Coordinator |
| Costume & Make-Up | Valentina Aulisi | Set Costumer |
| Camera | Neal Norton | Steadicam Operator |
| Camera | Vince McGahon | Steadicam Operator |
| Costume & Make-Up | Nadia Stacey | Other |
| Lighting | David Sinfield | Gaffer |
| Visual Effects | Alexandra Daunt Watney | Visual Effects Producer |
| Camera | Des Whelan | Camera Operator |
| Visual Effects | Daniel Barrow | Visual Effects Producer |
| Editing | Todd Kleparski | Digital Intermediate |
| Sound | Steve Little | Dialogue Editor |
| Visual Effects | David Vickery | Visual Effects Supervisor |
| Costume & Make-Up | Lesa Warrener | Makeup Artist |
| Costume & Make-Up | Lesa Warrener | Hairstylist |
| Art | Robert Griffon Jr. | Property Master |
| Visual Effects | Claudia Dehmel | Visual Effects Producer |
| Editing | Matthew Bristowe | Digital Intermediate |
| Crew | Laurent Hugueniot | CG Supervisor |
| Visual Effects | Tim Keene | Visual Effects Producer |
| Lighting | Tommy Finch | Rigging Gaffer |
| Crew | Helen Steinway Bailey | Stunts |
| Costume & Make-Up | Christine Blundell | Hair Designer |
| Costume & Make-Up | Christine Blundell | Makeup Designer |
| Costume & Make-Up | Charmaine Fuller | Hairstylist |
| Crew | Laura Jennings | Visual Effects Editor |
| Camera | Olly Tellett | First Assistant Camera |
| Camera | Alan Stewart | Second Unit Director of Photography |
| Art | Toni Barton | Assistant Art Director |
| Visual Effects | Chloe Harrison | Visual Effects Coordinator |
| Camera | John Flemming | Key Grip |
| Costume & Make-Up | Peter White | Set Costumer |
| Production | Emma Callinan | Casting Assistant |
| Camera | Louis Sabat | Dolly Grip |
| Crew | Rick Leary | CG Supervisor |
| Camera | Bobby Mancuso | First Assistant Camera |
| Costume & Make-Up | Charlotte Law | Assistant Costume Designer |
| Crew | Nick Jeffries | Armorer |
| Camera | Nick Ray | Key Grip |
| Sound | Steve Finn | Boom Operator |
| Costume & Make-Up | Carol 'Ci Ci' Campbell | Hairstylist |
| Costume & Make-Up | Martin Mandeville | Costume Coordinator |
| Camera | George Patsos | Key Grip |
| Art | Michael Auszura | Assistant Art Director |
| Sound | Paul Munro | Boom Operator |
| Visual Effects | Sarah Tulloch | Visual Effects Coordinator |
| Costume & Make-Up | Chloe Meddings | Hairstylist |
| Directing | Polly Hope | Script Supervisor |
| Art | Gabi Brown | Art Department Coordinator |
| Costume & Make-Up | Melissa Meister | Assistant Costume Designer |
| Costume & Make-Up | Paul Mooney | Hairstylist |
| Crew | Stephanie Lelievre | Stunts |
| Costume & Make-Up | Julia Wilson | Makeup Artist |
| Costume & Make-Up | Julia Wilson | Hairstylist |
| Visual Effects | Pawl Fulker | Pre-Visualization Supervisor |
| Lighting | Collin Quinlan | Chief Lighting Technician |
| Lighting | Greg Quinlan | Rigging Gaffer |
| Lighting | Gus Magalios | Rigging Grip |
| Visual Effects | Day Yargici | 2D Artist |
| Sound | Luke Neuman | Boom Operator |
| Art | Joseph K. Kepple IV | Art Department Coordinator |
| Art | John McDonnell | Assistant Property Master |
| Crew | Jodi Michelle Pynn | Stunts |
| Crew | Richard Dwyer | Stunts |
| Art | Joseph S. Alfieri | Construction Coordinator |
