Eight years after the third film, the OSS has become the world's top spy agency, while the Spy Kids department has since become defunct. A retired spy Marissa is thrown back into the action along with her stepchildren when a maniacal Timekeeper attempts to take over the world. In order to save the world, Rebecca and Cecil must team up with their hated stepmother. Carmen and Juni have since also grown up and will provide gadgets to them.
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| Directing | Robert Rodriguez | Director |
| Camera | Robert Rodriguez | Director of Photography |
| Production | Robert Rodriguez | Producer |
| Writing | Robert Rodriguez | Writer |
| Sound | Robert Rodriguez | Music |
| Production | Bob Weinstein | Executive Producer |
| Production | Harvey Weinstein | Executive Producer |
| Production | Elizabeth Avellan | Producer |
| Production | Mary Vernieu | Casting |
| Editing | Dan Zimmerman | Editor |
| Art | Steve Joyner | Production Design |
| Costume & Make-Up | Nina Proctor | Costume Design |
| Production | George Huang | Co-Producer |
| Production | Bill Scott | Line Producer |
| Costume & Make-Up | Gregory Nicotero | Special Effects Makeup Artist |
| Production | Matt Landon | Executive In Charge Of Post Production |
| Art | Marc Baird | Storyboard Artist |
| Production | Matthew Stein | Executive In Charge Of Production |
| Production | Rebecca Rodriguez | Co-Producer |
| Costume & Make-Up | Howard Berger | Makeup Artist |
| Production | Jessica Bradley | Art Department Production Assistant |
| Costume & Make-Up | Ermahn Ospina | Makeup Department Head |
| Costume & Make-Up | Joe Rivera | Key Hair Stylist |
| Sound | Carl Thiel | Music |
| Camera | Jimmy Lindsey | Director of Photography |
| Production | J.C. Cantu | Casting |
| Art | David Hack | Set Decoration |
| Costume & Make-Up | Jake Garber | Makeup Artist |
| Art | Jeff B. Adams Jr. | Set Designer |
| Art | Caylah Eddleblute | Production Design |
| Art | Ken Gaston-Kilgore | Set Dresser |
| Art | Edward J. Borasch Jr | Property Master |
| Costume & Make-Up | Becki Drake | Makeup Artist |
| Costume & Make-Up | Robert Ramos | Hairstylist |
| Crew | Steve Allen | Propmaker |
| Directing | Brian Bettwy | First Assistant Director |
| Production | Tom Proper | Associate Producer |
| Crew | Jackson Spidell | Stunts |
| Art | Mark Hanks | Leadman |
| Art | Jaime Fernandez | Assistant Property Master |
| Art | Jarid Boyce | Storyboard Artist |
| Art | Ted Altman | Props |
| Directing | David Rimer | Second Assistant Director |
| Art | Paul Alix | Concept Artist |
| Production | Elizabeth Kushman | Executive In Charge Of Production |
| Visual Effects | Alex Toader | Visual Effects Supervisor |
| Costume & Make-Up | Lauren Andersen | Makeup Artist |
| Directing | Vanessa Gaitan | Second Second Assistant Director |
| Art | Marcia Bruscato-Poss | Construction Buyer |
| Art | Brandon Campbell | Sculptor |
| Crew | Corey Childress | Carpenter |
| Art | Marc Dabrusin | Greensman |
